Background:

Control of transcription by RNA polymerase II involves the basal transcription machinery which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached while others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins.

Applications:

ELISA, IHC

Name of antibody:

TAF12

Immunogen:

Fusion protein of human TAF12

Full name:

TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa

Synonyms：

TAF2J; TAFII20

SwissProt:

Q16514

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human esophagus cancer and human ovarian cancer

IHC Recommend dilution:

25-100