Background:

Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells.

Applications:

WB

Name of antibody:

SYNE3

Immunogen:

Synthesized peptide derived from internal of human C14orf49.

Full name:

spectrin repeat containing, nuclear envelope family member 3

Synonyms：

NET53; Nesp3; C14orf49

SwissProt:

Q6ZMZ3

WB Predicted band size:

112 kDa

WB Positive control:

Jurkat cells lysate

WB Recommended dilution:

500-3000