Background:

The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, WB, IHC

Name of antibody:

SPP1

Immunogen:

Fusion protein of human SPP1

Full name:

secreted phosphoprotein 1

Synonyms：

OPN, BNSP, BSPI, ETA-1

SwissProt:

P10451

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human ovarian cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

34 kDa

WB Positive control:

OP9 cells

WB Recommended dilution:

200-1000