Background:

This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified.

Applications:

ELISA, IHC

Name of antibody:

SLC1A2

Immunogen:

Synthetic peptide of human SLC1A2

Full name:

solute carrier family 1 (glial high affinity glutamate transporter), member 2

Synonyms：

EAAT2, GLT-1

SwissProt:

P43004

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human brain and Human liver cancer

IHC Recommend dilution:

25-100