Background:

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.

Applications:

WB

Name of antibody:

SIRT1(Phospho-Ser47)

Immunogen:

Peptide sequence around phosphorylation site of serine 47(E-R-S(p)-P-G) derived from Human SirT1.

Full name:

sirtuin 1

Synonyms：

SIR2L1

SwissProt:

Q96EB6

WB Predicted band size:

82 kDa

WB Positive control:

Jurkat cells lysates

WB Recommended dilution:

500-1000