Background:

This gene encodes a member of the resistance to inhibitors of cholinesterase 3-like family which functions as a chaperone of specific 5-hydroxytryptamine type 3 receptor and nicotinic acetylcholine receptor subtypes. The encoded protein influences the folding and assembly of these receptor subunits in the endoplasmic reticulum and expression on the cell surface. This protein contains an N-terminal transmembrane domain, a proline-rich spacer, and a cytosolic C-terminal coiled-coil domain. Alternative splicing results in multiple transcript variants.

Applications:

ELISA, IHC

Name of antibody:

RIC3

Immunogen:

Fusion protein of human RIC3

Full name:

RIC3 acetylcholine receptor chaperone

Synonyms:

AYST720; PRO1385

SwissProt:

Q7Z5B4

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human tonsil and Human liver cancer

IHC Recommend dilution:

50-300